THE EFFECT OF INTRAUTERINE INSEMINATION PRECEDING FROZEN-THAWED ELECTIVE SINGLE EMBRYO TRANSFER IN COUPLES WITH UNEXPLAINED SUBFERTILITY

The effect of intrauterine insemination preceding frozen-thawed elective single embryo transfer in couples with unexplained subfertility

Introduction This prospective randomized controlled trial aimed to evaluate the effect of intrauterine insemination (IUI) before frozen-thawed elective single embryo transfer (FT-eSET).Material and methods A total of 200 couples with unexplained subfertility underwent in-vitro fertilization (IVF) treatment.Patients were randomly assigned to either

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The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress

Secretory cargo that cannot fold properly in the ER are selectively targeted for removal by a well-studied ER-associated degradation pathway, or ERAD.In contrast, very little is known about post-ER quality control mechanisms for damaged or misfolded integral membrane proteins.Here we describe a quality control function of the Rsp5-ART ubiquitin lig

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